A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-B

Figure 5

Effects of LOE on Ca/P-induced mRNA expression of MMP-2 and MMP-9 and gelatinolytic activities in VSMC supernatants. (a) Shown are the treatment dependent mRNA expression levels of MMP-2 and MMP-9 in murine VSMC after 24–48 h (). (b) Shown is a representative result of one measurement of gelatinolytic activities in VSMC supernatants by cleavage of DQ-gelatin and (c) the corresponding means ± SD of the respective endpoints of three independent measurements ( significant; , ).

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(b)

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