Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats

Table 2

Effects of Musa paradisiaca sap on castor oil-induced diarrhoea in Wistar rats.

	Distilled water	Loperamide (mg/kg body weight)	Musa paradisiaca sap (mL)
Parameters/dose (mL)	0	2.5	0.25	0.5	1.0
Onset time (min)	63.10 ± 1.60^a	122.30 ± 3.74^b	72.30 ± 2.62^c	97.40 ± 2.61^d	134.50 ± 2.62^e
Total number of feaces	5.11 ± 0.74^a	2.11 ± 0.59^b	3.89 ± 0.90^c	2.82 ± 0.26^d	2.30 ± 0.71^b
Number of wet feaces	4.33 ± 0.47^a	0.80 ± 0.12^b	1.94 ± 0.37^c	0.94 ± 0.13^d	0.67 ± 0.06^e
Fresh weight of feaces (g)	3.71 ± 0.21^a	0.71 ± 0.05^b	2.14 ± 0.37^c	0.87 ± 0.13^d	0.58 ± 0.02^b
Water content of feaces	1.78 ± 0.25^a	0.33 ± 0.06^b	1.08 ± 0.23^c	0.86 ± 0.12^c	0.36 ± 0.04^b
Inhibition of defecation (%)	0	58.70	23.80	44.80	54.90
Small intestine Na + K + ATPase activity (μmol Pi/mg protein/hour)	831.16 ± 10.44^a	1012.05 ± 13.68^b	1321.04 ± 13.19^c	1491.48 ± 9.60^d	1610.02 ± 15.11^e
Small intestine nitric oxide concentration (μmol/L)	162.14 ± 9.02^a	91.22 ± 7.54^b	92.29 ± 5.36^b	70.09 ± 7.09^c	56.27 ± 4.30^d

Data are mean of six determinations ± SEM. Test values with superscripts b, c, d, and e different from that of the castor oil-induced diarrhoea distilled water treated control, a, across the row for each parameter are significantly different ().