Inhibitory Effects of Cytosolic Ca²⁺ Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP₃RI and Dephosphorylation of ERK in Human Platelets

Figure 4

Effects of G-Ro on thrombin-induced mobilization. (a) Effects of G-Ro on level in thrombin-induced platelet aggregation. (b) Effects of G-Ro on level in the presence of A-kinase inhibitor (Rp-8-Br-cAMPS). (c) Effects of G-Ro on level in the presence of G-kinase inhibitor (Rp-8-Br-cGMPS). was determined as described in “Section 2.” The data are expressed as the mean ± standard deviation (). versus the thrombin-stimulated human platelets, versus the thrombin-stimulated human platelets in the presence of G-Ro (155 μM), and versus the thrombin-stimulated human platelets in the presence of G-Ro (300 μM).

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