Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis

Figure 7

Immunohistochemical detection of R in synovial membrane. Immunohistochemical analysis of synovial tissue from CIA-control mice revealed positive staining for R in contrast to Sham-control mice (b, a). The staining for R in CIA-EA mice was weaker than in CIA-control mice, but the difference was not significant (c, b). However, the staining for R was significantly increased in CIA-EA-SCH58261 mice (d, c) and in CIA-SCH58261 mice compared to the CIA-control mice (e, b). Values (IOD in %) are means ± SEM of 10 animals for each group. versus Sham-control. ^# versus CIA-EA (f). Magnification ×400 (a, b, c, d, and e).

(a) Sham-control

(b) CIA-control

(c) CIA-EA

(d) CIA-EA-SCH58261

(e) CIA-SCH58261

(f)