Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARγ in SHRs

Figure 5

Effects of 4-week treatment with gastrodin on systolic blood pressure (SBP) of rats. Ten-week-old male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHRs) were obtained. SHRs were randomly divided into model (SHR) and treatment groups (SHR + GAS). WKY were randomly divided into control (WKY) and treatment groups (WKY + GAS). The first two weeks was adaptation period. Starting from the third week, rats in SHR + GAS and WKY + GAS groups were intraperitoneally injected with gastrodin at the dose of 100 mg/(kg⋅d) for 4 weeks. The rest of the rats were not given any intervention. The SBP of the animals was recorded weekly during the experimental period. Values are shown as means ± SEM. versus WKY; , versus SHR.