Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study

Figure 1

Functional connectivity maps of controls and pretreatment and posttreatment groups were computed based on the pregenual ACC ROI (a). The left pregenual ACC seed region was connected with insula, dorsal lateral prefrontal cortex (dLPFC), medial prefrontal cortex, supramarginal gyrus, and superior and middle temporal gyri. The right pregenual ACC seed region was connected with insula, medial prefrontal cortex, middle cingulate gyrus, lateral prefrontal cortex, supramarginal gyrus, and middle temporal gyrus. Reduced connectivity was found in pretreatment group compared with healthy adults. These brain regions, termed disease targets, represent the regions associated with the FD disease (c). After treatment, connectivity was enhanced with the tendency to approximate the healthy controls. The connectivity values between pregenual ACC and the disease target were plotted for controls and pretreatment and posttreatment groups (b).

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