Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.
Table 3
The metabolic activity of single and mixed biofilms when exposed to bakuchiol was measured. Values represent absorbance using XTT reduction assay.
Biofilms
Untreated
Bakuchiol
Amphotericin B
Single species
C. albicans
1.042 ± 0.049†
0.417 ± 0.085α
0.266 ± 0.046α,β
C. dubliniensis
0.279 ± 0.016
0.274 ± 0.029
0.174 ± 0.026α,β
C. glabrata
0.723 ± 0.040†
0.896 ± 0.096
0.353 ± 0.061α,β
C. krusei
0.467 ± 0.048
0.400 ± 0.085
0.228 ± 0.079α,β
C. lusitaniae
0.192 ± 0.016
0.182 ± 0.017
0.242 ± 0.030α,β
C. tropicalis
0.351 ± 0.037
0.243 ± 0.032α
0.376 ± 0.056β
Mixed species
C. albicans
+ C. dubliniensis
0.435 ± 0.024
0.205 ± 0.015α
0.201 ± 0.023α
+ C. glabrata
1.023 ± 0.054†
0.962 ± 0.104
0.527 ± 0.036α,β
+ C. krusei
0.444 ± 0.014
0.315 ± 0.018α
0.330 ± 0.032β
+ C. lusitaniae
0.292 ± 0.013
0.246 ± 0.014
0.232 ± 0.025
+ C. tropicalis
0.289 ± 0.019
0.210 ± 0.025
0.198 ± 0.015β
† compared to others in their respective groups; single and mixed species biofilms. α compared to the untreated samples. β compared to bakuchiol-treated samples.