The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo

Figure 2

Contractile responses of mouse indirectly stimulated PND preparations incubated with Tyrode solution, CBA, and betulin (a) and B. jararacussu venom alone, venom + betulin, and venom + CBA (b). Note the facilitatory effect of betulin (alone and in the presence of venom). The points represent the mean ± SEM of the number of experiments () indicated in each panel. Note that in several cases the error bars are smaller than the symbol. compared to the Tyrode control (a) or venom alone (b). Note that, from 70 min onwards, the asterisks refer to the venom + betulin and venom + CBA curves.

(a)

(b)