The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo

Figure 4

Contractile responses of indirectly stimulated EPSTA preparations treated with saline (i.m.), venom (3.6 mg/kg, i.m., in 120 μL), and venom + CBA (1.8 μL in 1 mL, i.v.) (a) or betulin (20 mg in 1 mL, i.p.) and venom + betulin (b). Note the parallelism between the responses to betulin alone and venom + betulin. The points represent the mean ± SEM of the number of experiments () indicated in each panel. compared to saline and compared to venom alone. CBA and betulin were administered at the arrows 15 min after the venom.

(a)  

(b)