Comparator Study Mean difference 95% confidence interval valueHeterogeneity test , % df valueKnee OA—level of pain (various measures) NSAIDs
Chiranthanut et al., 2014 [11 ] 0.222 [−0.400, 0.844] NSAIDs Phromjuang, 2010 [15 ] 0.483 [−0.146, 1.112] NSAIDs Pooled effects (2 studies) [11 , 15 ]0.351 [−0.091, 0.793] ‡ 0.120 0.33 1 0.563 0.0 Knee exercise
Lekutai et al., 2008 [14 ] 1.430 [0.768–2.092] Knee exercise Sukonthasarn, 2004 [18 ] −0.100 [−0.720, 0.520] Knee exercise Pooled effects (2 studies) [14 , 18 ]0.660 [−0.839, 2.160] 0.388 10.92 1 0.001 90.8 Hot compress
Lekutai et al., 2008 [14 ] 0.207 [−0.301, 0.714] Hot compress Suwan, 2000 [19 ] 0.350 [−0.371, 1.072] Hot compress Pooled effects (2 studies ) [14 , 19 ]0.254 [−0.161, 0.669] ‡ 0.230 0.10 1 0.750 0.0 Combined comparators Pooled effects (5 studies) [11 , 14 , 15 , 18 , 19 ]0.419 [−0.004, 0.842] ‡ 0.052 9.58 4 0.048 58.3 Knee OA—difficulty in performing activities (various measures) NSAIDs
Chiranthanut et al., 2014 [11 ] 0.544 [−0.088, 1.176] Knee exercise
Lekutai et al., 2008 [14 ] 0.230 [−0.805, 1.265] Knee exercise Sukonthasarn, 2004 [18 ] −0.450 [−1.893, 0.993] Knee exercise Pooled effects (2 studies) [14 , 18 ]−0.001 [−0.842, 0.840] 0.998 0.56 1 0.453 0.0 Hot compress Lekutai, 2008 [14 ] −0.059 [−0.565, 0.447] Hot compress Suwan, 2000 [19 ] 0.610 [−0.123, 1.343] Hot compress Pooled effects (2 studies) [14 , 19 ]0.221 [−0.426, 0.868] ‡ 0.504 2.17 1 0.141 53.9 Combined comparators Pooled effects (4 studies) [11 , 14 , 18 , 19 ]0.224 [−0.128, 0.577] ‡ 0.213 4.48 3 0.242 28.3 Muscle pain—level of pain (VAS of pain, score range 0–10) NSAIDs
Sathianrat et al., 2003 [17 ] 0.300 [−0.539, 1.139] Hot compress
Puengsuwan et al., 2009 [16 ] −0.280 [−1.613, 1.053] Hot compress
Sathianrat et al., 2003 [17 ] 1.130 [0.300, 1.960] Hot compress Pooled effects (2 studies) [16 , 17 ]0.525 [−0.842, 1.893] 0.452 3.10 1 0.078 67.7 Combined comparators Pooled effects (2 studies) [16 , 17 ]0.135 [−0.574, 0.845] 0.708 0.52 1 0.470 0.0 Induce lactation (duration from delivery to milk secretion, minutes) Routine program
Listisit and Pakdeechot, 2009 [20 ] −318.500 [−501.015, −35.985] Routine program
Pakdeechot et al., 2010 [21 ] −528.240 [−903.301, −153.179] Routine program Pooled effects (2 studies) [20 , 21 ]−394.425 [−620.084, −168.766] 0.001 0.77 1 0.381 0.0