Review Article
Molecular and Functional Characterization of Bacopa monniera: A Retrospective Review
Table 1
Summary of Bacopa monniera treatment effects on serotonergic system and its associated pathway.
| Neurotransmitters | Effects | Genes (mRNA) | Effects | Genes (Protein) | Effects | References |
| Serotonin |
↑ | Tph2 | ↑ | | |
[35] | SERT | ↑ |
| Serotonin Dopamine Acetylcholine GABA Glutamate |
↑ ↓ ↑ ↑ ↑ | 5-HT1A | — | | | | 5-HT2A | ↑ | | | | 5-HT3A | ↑ | | | | 5-HT4 | — | | | [41] | 5-HT5 | — | | | | 5-HT6 | — | | | | 5-HT7 | ↓ | | | |
| | | Nrf2 | ↑ | SYP SYT t-αCaMKII p-αCaMKII PSD-95 | ↑ ↑ ↑ ↑ ↑ | [43] |
| | | Dicer Ago2 miR-124 Creb1 | ↓ ↓ ↓ ↑ | DICER AGO2 t-CREB1/2 p-CREB1/2 | ↓ ↓ ↑ ↑ | [39] |
| | | Bdnf PP1α | ↑ ↓ | t-ERK1/2 | ↑ | | p-ERK1/2 | ↑ | t-CREB1/2 | ↑ | p-CREB1/2 | ↑ | Ac-H3 | ↑ |
[42] | Ac-H4 | ↑ | HDAC1 | ↓ | | HDAC2 | ↓ | p300 | ↑ | PP2A | ↓ |
|
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↓: decrease; ↑: increase.
|