GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Figure 4

Effect of flumazenil on the anxiolytic activity of carnosol, oleanolic acid, and ursolic acid in the elevated plus maze. (a) % of open-arm entries and (b) % of time spent in open arms registered over a session of 5 min after 20 min of an i.p. injection of vehicle, diazepam (1 mg/kg), carnosol, oleanolic acid, and ursolic acid (10 mg/kg) in the presence of flumazenil (2.5 mg/kg). Columns express mean ± SEM (/group). and compared with vehicle control group using one-way ANOVA followed by Dunnett’s test.

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