GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Table 1

Effect of carnosol, ursolic acid, and oleanolic acid on immobility period (sec) of mice using tail suspension test.

Group	Treatment	Dose (mg/kg)	Immobility time (sec)
1	Control	—	170 ± 10.5
2	Carnosol	10	139.4 ± 13.5
3		30	115.7 ± 11.3
4		100	100.5 ± 10.2
5	Ursolic acid	10	135.4 ± 14.8
6		30	115.3 ± 11.5
7		100	105.1 ± 10.4
8	Oleanolic acid	10	125.8 ± 5.2
9		30	115.3 ± 10.3
10		100	95.6 ± 15.1
11	Imipramine	60	60.2 ± 11.6

All values are expressed in mean ± SEM (). , , and compared to the vehicle group. Differences between groups were analyzed by analysis of variance (one-way ANOVA) followed by Dunnett’s test.