GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Table 2

Effect of carnosol, ursolic acid, and oleanolic acid on immobility period (sec) of mice using forced swimming test.

Group	Treatment	Dose (mg/kg)	Immobility time (sec)
1	Control	—	184.6 ± 13.5
2	Carnosol	10	149.4 ± 10.5
3		30	125.7 ± 12.3
4		100	80.5 ± 11.2
5	Ursolic acid	10	135.4 ± 10.5
6		30	120.3 ± 11.4
7		100	74.9 ± 10.5
8	Oleanolic acid	10	148.8 ± 10.2
9		30	125.3 ± 11.3
10		100	95.6 ± 14.1
11	Imipramine	60	70.2 ± 12.6

All values are expressed in mean ± SEM (). , , and compared to the vehicle group. Differences between groups were analyzed by analysis of variance (one-way ANOVA) followed by Dunnett’s test.