Research Article
GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn
Table 4
Effect of carnosol, ursolic acid, and oleanolic acid on PTZ-induced seizure.
| Treatment | Dose (mg/kg) | Onset of clonic-tonic convulsions (sec) | Duration of clonic-tonic convulsions (sec) | % mortality | % protection against mortality |
| Control | — | 72.5 ± 8.5 | 39 ± 4.5 | 100% | 0 | Diazepam | 1 | 197 ± 10.6 | 15.8 ± 2.6 | 0.00 | 100 | Carnosol | 1 | 77.1 ± 12.9 | 35 ± 3.5 | 66.6 | 33.34 | Carnosol | 10 | 117.3 ± 6.8 | 26 ± 2.6 | 33.3 | 66.67 | Carnosol | 30 | 158.3 ± 11.6 | 17.6 ± 1.8 | 16.3 | 83.33 | Carnosol | 100 | 185.8 ± 8.8 | 7.5 ± 1.1 | 0.00 | 100 | Ursolic acid | 1 | 75.1 ± 13.5 | 33 ± 3.5 | 66.6 | 33.34 | Ursolic acid | 10 | 120.3 ± 7.5 | 25 ± 3.6 | 33.3 | 66.67 | Ursolic acid | 30 | 148.5 ± 11.5 | 19.6 ± 2.8 | 16.3 | 83.33 | Ursolic acid | 100 | 195.8 ± 8.8 | 15.5 ± 2.5 | 0.00 | 100 | Oleanolic acid | 1 | 78.1 ± 14.5 | 34 ± 3.5 | 66.6 | 33.34 | Oleanolic acid | 10 | 130.3 ± 9.5 | 23 ± 2.6 | 33.3 | 66.67 | Oleanolic acid | 30 | 150.8 ± 13.5 | 18.5 ± 2.8 | 16.3 | 83.33 | Oleanolic acid | 100 | 190.8 ± 8.8 | 14.5 ± 2.5 | 0.00 | 100 |
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The data represent the mean ± SEM (). , , and represent significant difference compared to PTZ-induced seizure control. n.s.: not significant.
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