Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats

Figure 7

Temporal changes in C-reactive protein (CRP) (a) and serum amyloid A (SAA) levels (b) in rats administered sequential/nonsequential treatments. Panels (a1)–(a4) and (b1)–(b4) from panels (a) and (b) indicate the comparisons of the sequential and nonsequential treatment with traditional Chinese medicine, Western medicine, or integrated medicines, respectively. AE: acute exacerbation; BYG: Bufei Yishen Granule; COPD: chronic obstructive pulmonary disease; MXF: moxifloxacin; NS: normal saline; RW: risk window; TSG: Tongsai Granule; STL: salbutamol. . Repetitive measurement deviation analysis of CRP and SAA levels: . , versus Control group; , versus COPD group; , versus AECOPD group; , versus TSG/NS group; , versus MXF+STL/NS group; , versus TSG/BYG group; , versus MXF+STL/STL group. Bacterial challenge was performed on Day 1.

(a)

(b)