Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis

Figure 3

Effect of treatment with ethanolic extract (EE) of babassu mesocarp on the production of cytokines. The animals were treated with EE at doses of 125 (EE125) or 250 mg/Kg (EE250) 6 h after the induction of sepsis by cecal ligation and puncture and compared to the untreated group also submitted to the inductions of sepsis (CLP) or not (Sham). The animals were sacrificed 12 h after the procedure and serum was obtained for the measurement of IL-6 (a), TNF-α (b), and IFN-γ (c) by ELISA assay. The results are expressed as mean ± SEM (5 animals/group). () < 0,05 in comparison to the SHAM group and () < 0,05 in comparison to the CLP group.

(a)

(b)

(c)