Effects of Guchang Capsule on Dextran Sulphate Sodium-Induced Experimental Ulcerative Colitis in Mice

Figure 3

GC administration decreased proinflammatory cytokines production in DSS-treated mice. (a) ELISA analysis of secreted proinflammatory cytokines; (b) qPCR analysis of mRNA level of proinflammatory cytokines. Colitis was induced by administration of 4% DSS for 6 d. GC were given intragastrically once per day for 6 days from the first day, respectively. The mice were sacrificed at day 6. The protein level (a) or mRNA level (b) of TNFα, IL-6, and IL-1β in distal part of colons was analyzed. The data are representative of three independent experiments ( per group, mean ± SD). versus control + DSS group, versus control + DSS group, and versus control group.

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