Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro

Table 3

Concentration of single drugs and combination drug used in inhibiting cold-induced upregulation of TRPM8.

Single drug (M)		Combination drug (M)		Total concentration
Ferulic acid	Z-ligustilide	Ferulic acid	Z-ligustilide
3.125	3.125	3.4	2.3	5.7
6.25	6.25	6.8	4.7	11.5
12.5	12.5	13.7	9.3	23
25	25	27.3	18.6	45.9