Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation

<div>THL decreased G2/M-related cyclins A and B1 in MCF-7 cells. (a) THL decreased cyclin A and cyclin B1 protein levels in a dose-dependent manner but did not significantly change the Cdc2 (CDK1) protein level. Cells were treated with PBS or THL (0.75, 1.5, 3, and 6 mg/mL) for 72 h and then harvested. Cell lysates were then prepared for Western blot analysis. (b) The blots were normalized to actin or tubulin, and the fold change in protein expression levels in comparison to the PBS-treated control is depicted in this panel.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation 

Figure 3 | Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation 