Research Article
Acute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract of Dicoma anomala Sond. in Wistar Rats
Table 4
Haematological data for female rats given aqueous root extracts of Dicoma anomala for 90 days.
| Parameters | Unit | Dose (mg/kg/day) | Control | 125 | 250 | 500 |
| RBC | millions/µL | 7.45 ± 0.10 | 7.44 ± 0.01 | 7.53 ± 0.05 | 7.88 ± 0.02 | Haemoglobin | g/dL | 14.41 ± 0.01 | 13.96 ± 0.02 | 15.09 ± 0.01 | 15.19 ± 0.01 | Haematocrit | L/L | 0.50 ± 0.05 | 0.49 ± 0.01 | 0.56 ± 0.02 | 0.59 ± 0.00 | MCV | fL | 61.00 ± 0.00 | 60.00 ± 0.00 | 62.00 ±0.00 | 63.00 ± 0.00 | MCH | pg | 16.00 ± 0.01 | 17.00 ± 0.01 | 17.00 ± 0.01 | 18.00 ± 0.01 | MCHC | g/dL | 27.00 ± 0.10 | 27.00 ± 0.10 | 28.00 ± 0.10 | 28.00 ± 0.10 | RDW | fL | 10.60 ± 0.01 | 11.40 ± 0.10 | 11.09 ± 0.00 | 11.91 ± 0.2 | WBC | thous/µL | 5.80 ± 0.02 | 6.30 ± 0.01 | 6.70 ± 0.02 | 6.91 ± 0.02 | Neutrophils | ×109/L | 0.12 ± 0.00 | 0.16 ± 0.01 | 0.15 ± 0.02 | 0.16 ± 0.01 | Lymphocytes | % | 4.08 ± 0.10 | 4.05 ± 0.20 | 4.07 ± 0.20 | 4.80 ± 0.10 | Monocytes | % | 0.73 ± 0.00 | 0.93 ± 0.01 | 1.08 ± 0.01 | 1.12 ± 0.02 | Eosinophils | ×109/L | 0.09 ± 0.00 | 0.12 ± 0.02 | 0.08 ± 0.00 | 0.08 ± 0.00 | Basophils | ×109/L | 0.01 ± 0.00 | 0.02 ± 0.00 | 0.03 ± 0.01 | 0.02 ± 0.01 | Platelet | thous/L | 1007.00 ± 0.50 | 893.00 ± 0.03 | 871.00 ± 0.10 | 944.00 ± 0.49 |
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Values are presented as mean ± SEM (). Significantly different compared to control at .
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