Research Article
Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial
Table 3
Clinical secondary outcomes.
| Secondary outcome factors | Study group | Control group | value | () | () |
| Heart rate (beats/min) | | | | Before intervention | 122.80 ± 20.89 | 113.22 ± 27.25 | 0.106 | 72 h after intervention | 91.63 ± 17.96 | 112.38 ± 29.13 | 0.042 | Mean artery pressure (mmHg) | | | | Before intervention | 70.43 ± 19.84 | 74.94 ± 19.25 | 0.297 | 72 h after intervention | 81.35 ± 15.48 | 75.02 ± 18.02 | 0.093 | Respiratory frequency (breaths/min) | | | | Before intervention | 25.55 ± 8.19 | 25.78 ± 6.65 | 0.282 | 72 h after intervention | 19.87 ± 5.39 | 23.36 ± 6.05 | 0.019 | Arterial partial pressure of oxygen (PaO2, mmHg) | | | | Before intervention | 82.15 ± 45.99 | 74.51 ± 35.37 | 0.651 | 72 h after intervention | 107.83 ± 41.51 | 81.41 ± 39.97 | 0.015 | Leucocyte counts (109/L) | | | | Before intervention | 16.22 ± 8.72 | 14.82 ± 8.57 | 0.926 | 72 h after intervention | 12.05 ± 7.75 | 17.21 ± 8.16 | 0.013 | Urinary production per hour (mL/hour) | | | | Before intervention | 68.28 ± 40.40 | 74.12 ± 52.99 | 0.555 | 72 h after intervention | 130.14 ± 93.53 | 65.7 ± 41.52 | 0.002 | Platelet counts (109/L) | | | | Before intervention | 163.38 ± 120.02 | 155.83 ± 84.91 | 0.454 | 72 h after intervention | 156.10 ± 104.79 | 108.26 ± 64.13 | 0.018 | Lactate level (mmol/L) | | | | Before intervention | 4.68 ± 3.32 | 4.61 ± 3.55 | 0.937 | 72 h after intervention | 2.48 ± 2.26 | 4.40 ± 3.41 | 0.006 | Bilirubin (µmol/L) | | | | Difference before and 72 h after intervention | 13.65 (4.50, 53.10) | 17.00 (3.50, 249.63) | 0.844 | Creatinine (mmol/L) | | | | Before intervention | 137.22 ± 58.62 | 136.80 ± 65.47 | 0.976 | 72 h after intervention | 126.52 ± 68.61 | 160.73 ± 92.27 | 0.06 | Rate of voluntary termination of treatment (%) | 32.5% (13/40) | 23.80% (10/42) | 0.381 | Days of ICU hospitalization (days) | 8.23 ± 5.25 | 8.12 ± 10.19 | 0.951 | Days of mechanical ventilation (days) | 3.60 ± 4.14 | 3.70 ± 4.29 | 0.928 |
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