Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic db/db Mice

Figure 5

Effects of SMS on TGF-β associated downstream signaling. Protein expression was determined in the whole cell lysate via Western blotting and quantified by densitometric analysis. (a) Protein expression band. (b–e) Quantified value of protein expression. Data presented are means ± SEM (3 heart tissues from each group). versus Control group; versus db/db group. TGF-β1, transforming growth factor-β1; TGFβRII, transforming growth factor-β receptor II; p-Smad2, phosphorylated Smad2; p-Smad3, phosphorylated Smad3; t-Smad2, total Smad2; t-Smad3, total Smad3; MMP-2, matrix metallopeptidase 2; MMP-9, matrix metallopeptidase 9; TIMP-2, tissue inhibitor of metalloproteinases-2.

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