Research Article
Guizhi Fuling Wan, a Traditional Chinese Herbal Formula, Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Inactivation of the PI3K/AKT/mTOR Pathway
Figure 4
Rat medicated sera containing GFW inhibit MDR involved in P-gp and the PI3K/AKT/mTOR signalling pathway by Western blotting analysis in SKOV3/DDP cells after treated for 72 h. (a) Representative Western blotting gel results. (b) Bar graphs for relative protein levels. The results are the mean ± SD of at least 3 independent experiments. -actin was used as an endogenous control and densitometric values were normalized by β-actin. , . LD sera represent the rat medicated sera corresponding to the GFW dosage of 4 g·kg−1·d−1. MD sera represent the rat medicated sera corresponding to the GFW dosage of 8 gkg−1d−1. HD sera represent the rat medicated sera corresponding to the GFW dosage of 16 gkg−1d−1.
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