Guizhi Fuling Wan, a Traditional Chinese Herbal Formula, Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Inactivation of the PI3K/AKT/mTOR Pathway

Table 1

Cytotoxicity of the LD sera or VER in combination with cisplatin or paclitaxel in SKOV3 and SKOV3/DDP cells in vitro.

Drug and concentration	IC50 (mg·L^−1)		Resistance fold	Reversal fold
	SKOV3	SKOV3/DDP
Cisplatin	3.58 ± 0.12	14.79 ± 0.41	4.13
Paclitaxel	1.78 ± 0.31	6.86 ± 0.22	3.85
LD sera + cisplatin	3.22 ± 0.08	4.39 ± 0.17	1.36	3.04
LD sera + paclitaxel	1.59 ± 0.27	2.33 ± 0.42	1.47	2.62
VER + cisplatin	3.34 ± 0.13	4.09 ± 0.29^#	1.22	3.39
VER + paclitaxel	1.69 ± 0.24	1.95 ± 0.30^#	1.18	3.26

LD, low-dose. VER, verapamil. P < 0.01 compared with each other, ^#P < 0.01 compared with each other.