Metabolomic Analysis of Biochemical Changes in the Plasma of High-Fat Diet and Streptozotocin-Induced Diabetic Rats after Treatment with Isoflavones Extract of Radix Puerariae
Table 3
Identification results of main potential biomarkers changes.
Number
RT (min)
Formula
Mass ()
Potential biomarkers
Diabetic versus Normal
Treatment versus Diabetic
1
8.83
C15H31N5O5
362.24
Lys-Lys-Ser
↑
↓##
2
9.27
C21H42N6O6
475.33
Leu-Ser-Lys-Lys
↑
↓##
3
9.65
C29H60NO7P
566.43
PC(21:0/0:0)[U]
↓
↑##
4
15.79
C9H20O3
177.15
2-Hexylglycerol
↓
↑#
5
16.65
C8H14O3
159.1
7-Keto-n-caprylic acid
↓
↑#
6
20.65
C11H15N5O3S
298.1
5′-Methylthioadenosine
↑
↓##
7
21.18
C7H12O3
145.08
7-Oxoheptanoic acid
↓
↑##
8
21.59
C31H46O2
451.36
Phylloquinone
↑
↓##
9
28.38
C42H84NO8P
784.58
PC(22:0/12:0)
↑
↓#
10
28.79
C16H27N9O5
425.21
Gly-His-Arg-Gly
↑
↓##
11
29.45
C46H82NO8P
808.58
PC(20:4(5Z,8Z,11Z,14Z)/18:1(11Z))
↑
↓##
“↑” and “↓” represent upregulation and downregulation. and indicate a significant difference as compared with normal rats; #, ## indicate a significant difference as compared with diabetic rats.
