Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury

Figure 1

Cytotoxicity and proliferation of Salvianolate in AML-12 cell lines. (a) AML-12 cells were cultured in a 96-well plate at a density of 5,000 cells/well and incubated with Salvianolate with concentrations of 3.125–400 μg/mL for 24 h. (b) AML-12 cells were cultured in a 96-well plate at a density of 5,000 cells/well and exposed to 0.5 mM H₂O₂ for 20 min; then the cells were incubated with Salvianolate with concentrations of 6.25–25 μg/mL or NAC with concentration of 10 mM for 24 h. Both cytotoxicity of Salvianolate and proliferation of Salvianolate or NAC were detected by CCK8. and versus normal control; and versus model control.

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(b)