Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury

Figure 5

Salvianolate relieved mitochondrial injury in hepatocytes. Normal hepatocytes and mitochondria were observed in normal group. However, after stimulating with CCl₄, cellular nucleus concentrating, mitochondria swelling and mitochondria cristae fragmentation or disappearance, and so forth were commonly seen in model control (marked with red arrows). Meanwhile, all those pathological changes were ameliorated after the rats were given 40 mg/kg Salvianolate or NAC. Images of TEM for mitochondria in hepatocytes ×13800.