Effects of Jia-Wei-Xiao-Yao-San on the Peripheral and Lymphatic Pharmacokinetics of Paclitaxel in Rats

Figure 2

Representative chromatograms of paclitaxel in rat plasma and lymph. (a) Blank rat plasma; (b) blank rat plasma sample spiked with paclitaxel (250 ng/mL) and docetaxel (IS); (c) real rat plasma sample containing paclitaxel (270 ng/mL) collected at 390 min after administration of paclitaxel (5 mg/kg, i.v. infusion). (d) Blank rat lymph; (e) blank rat lymph sample spiked with paclitaxel (250 ng/mL) and docetaxel (IS); (f) real rat lymph sample containing paclitaxel (245 ng/mL) collected from 330 to 360 min after administration of paclitaxel (5 mg/kg, i.v. infusion). 1: paclitaxel; 2: docetaxel (IS, 250 ng/mL).

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