Synergism Effect of the Essential Oil from Ocimum basilicum var. Maria Bonita and Its Major Components with Fluconazole and Its Influence on Ergosterol Biosynthesis

Figure 5

Transmission electron microscopy of C. albicans fluconazole sensitive strain treated with 625 μg/mL of EO and 76 μg/mL of geraniol for 48 h at 37°C. The control (untreated) C. albicans sensitive strain cells showed good preservation of cell wall and membrane (a and b). Cells treated with 625 μg/mL of EO presented cell wall thickening (c and d) and the treatment with 76 μg/mL of geraniol led to the appearance of cell membrane invaginations presenting some vesicles and the thickening of the cell wall (e and f).

(a)

(b)

(c)

(d)

(e)

(f)