The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Table 1

Experimental design.

Groups	1st week	2nd-3rd week	3rd weekend	4th–6th week	7th week
Control; ()	Behavioral tests	SE; ()	Sucrose preference & open field test	SE; ()	Behavioral tests
Stress; ()	Behavioral tests	CUMS ()	Sucrose preference & open field test	CUMS + water ()	Behavioral tests
Stress + Flu ()	Behavioral tests	CUMS )	Sucrose preference & open field test	CUMS + Flu ()	Behavioral tests
Stress + AS ()	Behavioral tests	CUMS ()	Sucrose preference & open field test	CUMS + AS ()	Behavioral tests

SE: standard environment; CUMS: chronic unpredictable mild stress; behavioral tests: sucrose preference & open field & forced swim tests.
There are 44 rats in the start of experiment: control (), stress (), stress + Flu (), and stress + AS ().
The animal number of each group is eight in end stage.