Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice

Figure 4

Effects of piperine on TLR-2 and TLR-4. The mRNA levels of TLR-2 and TLR-4 in uterus tissues. qPCR was performed to detect the TLR-2 and TLR-4 mRNA levels. GAPDH was used as a control. CG: control group, the mice without any treatment. S. aureus: the mouse model of S. aureus endometritis without any drug treatment. 25, 50, and 100: piperine treatment groups: the S. aureus endometritis mice were given piperine at 25 mg/kg, 50 mg/kg, and 100 mg/kg. DEX: the S. aureus endometritis mice were treated with dexamethasone at 5 mg/kg. The data are represented as the mean ± SD. is significantly different from the CG; is significantly different from the S. aureus group.