Veratri Nigri Rhizoma et Radix (<i>Veratrum nigrum</i> L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPK<i>α</i>-ACC Axis<i> In Vivo</i> and<i> In Vitro</i>

<div>HPLC analysis of VN and effects of VN and its compound jervine on 3T3-L1 adipocytes. (a) HPLC-PDA measurement of VN demonstrated various chromatographic peaks. By comparing chromatographic peaks with reference chromatographic peaks, jervine was identified. (b) The effects of VN and jervine on lipid accumulation during 3T3-L1 adipogenesis were compared by an Oil Red O staining assay. (c) The effects of VN and jervine on adipogenic genes,<i> PPAR<i>γ</i></i> and<i> C/EBP<i>α</i></i>, expressions were compared using a Real-Time RT-PCR assay. 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Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Veratri Nigri Rhizoma et Radix (<i>Veratrum nigrum</i> L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPK<i>α</i>-ACC Axis<i> In Vivo</i> and<i> In Vitro</i> 

Figure 2 | Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro 