ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

Figure 3

Effects of ESP-102 on long-term potentiation (LTP) and long-term depression (LTD) in hippocampal tissue of rats treated with scopolamine (–6/group). (a) Grouped data showing time course of LTP from all recordings made from hippocampal tissue treated with ESP-102 (10 μg/mL), scopolamine (10 μM), and scopolamine + ESP-102. (b) Average LTP amplitude measured 30–40 min after HFS. (c) Grouped data showing time course of LTD from all recordings made from hippocampal tissue treated with ESP-102 (10 μg/mL), scopolamine (10 μM), and scopolamine + ESP-102. (d) Average LTD amplitude measured 30–40 min after HFS. versus control group. versus scopolamine group.

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