ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

Figure 4

Effects of ESP-102 and antagonists AP-5 and CNQX on long-term potentiation (LTP) in rat hippocampal tissue (–5/group). (a) Grouped data showing time course of LTP from all recordings made from hippocampal tissue treated with ESP-102 (10 μg/mL), AP5 (10 μM), and AP5 + ESP-102. (b, d) Average LTP amplitude measured 30–40 min after HFS. (c) Grouped data showing time course of LTP from all recordings made from hippocampal tissue treated with ESP-102 (10 μg/mL), CNQX (10 μM), and CNQX + ESP-102. Means with different letters differ at () level by ANOVA and Duncan’s multiple range test and two-tailed Student’s -test.

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