ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

Figure 5

Effects of ESP-102 on the protein expression of brain-derived neurotrophic factor (BDNF) and glutamate receptor-2 (GluR-2) in rats with scopolamine-induced hippocampal impairment by western blot analysis (/group). (a) Protein levels of BDNF in rat hippocampus were measured by western blot analysis using anti-BDNF specific antibody. β-actin levels were assessed to confirm equal protein loading. Quantitative analysis of relative band intensity for BDNF/β-actin is represented in the graph. (b) Protein levels of GluR-2 in rat hippocampus were measured using anti-GluR-2 specific antibody. Quantitative analysis of relative band intensity for GluR-2/β-actin is represented in the graph. Band 1: control group; Band 2: scopolamine; Band 3: ESP-102; Band 4: scopolamine and ESP-102. The data were normalized against β-actin levels and expressed as percentage of control values. versus control group. , versus scopolamine group.

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