Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats

Table 3

Semiquantitative scoring of the architectural changes evidenced by histopathological examination of the rats’ livers and kidneys.

Scoring parameter	Group
	1	2	3	4	5	6	7
	Liver
Degeneration of hepatocytes	—	—	+++	++	++	+	+
Inflammatory cell infiltration	—	—	+++	++	++	+	+
Vascular congestion	—	—	+++	++	+	—	+
Edema	—	—	+++	++	++	+	+
	Kidney
Tubular necrosis	—	—	+++	++	++	+	+
Vacuolization	—	—	+++	+	++	+	+
Glomerular necrosis	—	—	+++	++	++	+	++

Scoring was performed as follows: none (—), mild (+), moderate (++), and severe (+++).
Group 1 = control; Group 2 = EECM; Group 3 = APAP; Group 4 = T 250; Group 5 = T 500; Group 6 = T 1000; and Group 7 = silymarin.