Research Article
Mechanisms of P-Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba
Table 2
Effect of RPAE on strychnine transport in MDCK-MDR1 cells (
, ).
| Groups | (×10−6 cm/s) | (×10−6 cm/s) | ER |
| 1 μg/mL SSE | 28.33 ± 2.67 | 39.39 ± 11.75 | 1.39 ± 4.40 | 1 μg/mL SSE + 1 μg/mL RPAE | 24.49 ± 1.63 | 30.73 ± 0.64 | 1.25 ± 0.39 | 1 μg/mL SSE + 3 μg/mL RPAE | 22.29 ± 8.19 | 37.39 ± 0.95 | 1.68 ± 0.12 | 1 μg/mL SSE + 6 μg/mL RPAE | | 41.92 ± 1.53 | 2.13 ± 0.67 | 1 μg/mL SSE + 100 μM verapamil | | 39.57 ± 1.53 | 0.90 ± 0.38 |
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with contrast to the SSE 1 μg/mL group; with contrast to groups without verapamil.
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