Oleuropein Protects Cardiomyocyte against Apoptosis via Activating the Reperfusion Injury Salvage Kinase Pathway In Vitro

Figure 5

Oleuropein modulated Bcl-2, Bax, cleaved caspase-3, cleaved caspase-9, and Cyt-C expression in neonatal rat cardiomyocytes subjected to SI/R. (a) SI/R upregulated Bax expression and downregulated Bcl-2 expression, hence decreasing the Bcl-2/Bax ratio compared to the control cells, but 400 µg/mL oleuropein increased the Bcl-2/Bax ratio. (b) SI/R significantly increased expression of Cyt-C, cleaved caspase-3, and cleaved caspase-9, which were attenuated by 400 µg/mL oleuropein treatment. All data were presented as mean ± SE (). SI/R: simulated ischemia/reperfusion. , versus control; , versus SI/R.

(a)

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