Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway

Figure 8

Wogonin decreased Aβ aggregates (high molecular weight oligomers) in the cerebral tissue of three 3xTg-AD mice. 3xTg-AD mice were given injection intraperitoneally with vehicle/wogonin (10 mg/kg) every other day from the 8th to the 24th week of age. Mice were sacrificed when they were 24 weeks old, and cerebellar extracts were subjected to western blot analysis. (a) Aggregation of Aβ on cerebellar extracts of 3xTg-AD mice was measured by using a 6E10 antibody. (b) Relative intensity of Aβ aggregates was presented with ImageJ. Actin was used as a loading control. The results are shown as mean ± SEM, .

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