Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

Figure 3

Increased hypothalamic endoplasmic reticulum (ER) stress in high-fat diet- (HFD-) fed mice. (a) Time dependence of body weight in low-fat diet- (LFD-) and HFD-fed mice. At 12 weeks of age, HFD-fed mice showed significantly higher body weight than those fed with LFD. (b) mRNA expression levels of ER stress response markers in LFD- and HFD-fed mice. HFD dramatically upregulated the mRNA expression levels of ER stress response markers in obese mice. The results are the means ± SDs (). values (; ) indicate significant differences compared to those of LFD-fed mice.

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