Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

Figure 4

Effect of central administration of 1-deoxynojirimycin (DNJ) on endoplasmic reticulum (ER) stress response markers and ER chaperones/foldase expression in high-fat diet- (HFD-) fed mice. (a) Effects of intracerebroventricular (ICV) administration of 50 μg/mL DNJ (1 μL) on hypothalamic ER stress responsive markers and ER chaperones/foldases. (b) Effects of ICV administration of 50 μg/mL DNJ (1 μL) on hypothalamic mRNA expression of hypothalamic ER stress responsive markers. The results are the means ± SDs ( per group). The results of densitometric analysis are the means ± SDs (). values (; ; ) indicate significant differences compared with vehicle (1 μL of distilled water; DW). HFD/DNJ (+/−), central administration of vehicle of HFD-fed group. HFD/DNJ (+/+), central administration of DNJ of HFD-fed group.

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