Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective

Figure 2

The basic structure of the arachidonic acid metabolic network associated with inflammatory processes. When phospholipid is catalyzed by cPLA2 into arachidonic acid, there are two major pathways (5-LOX and COX-1/2) in this network. Each circled product is catalyzed by the cognate protein nearby while the arrow indicates the metabolic direction.