Research Article
A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease
Figure 1
GNC delayed Aβ-induced paralysis in transgenic C. elegans CL4176 at 25°C. (a) Representative image of transgenic C. elegans CL4176 showing paralysis caused by Aβ expression. Representative images of control worms (no temperature shift) at 16°C and the effect of the temperature increase to 25°C for 29 h to induce Aβ expression in control and GNC-treated (3.94 mg/mL) transgenic C. elegans CL4176 are shown. (b) Curves show the course of Aβ-induced paralysis in transgenic C. elegans CL4176 treated with a vehicle control (H2O) or various doses of GNC. GNC increased the time to paralysis onset in CL4176 worms in a dose-dependent manner (at least 35 worms were tested in each group, and the experiments were performed more than 3 times).
| (a) |
| (b) |