Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats

Figure 2

SZF improved the kidney function of rats with OA-induced hyperuricemia. (a) Changes in animal weight over the 7 weeks of animal modelling and treatment; OA: oxonic acid potassium salt; (b) changes in Sua in the tail vein over the 7 weeks of animal modelling and treatment and the 24 h urinary UA excretion conditions at the end of the 7 weeks; UA: uric acid; Sua: serum uric acid; Uua: 24 h urinary uric acid excretion; (c) BUN and Scr levels in the abdominal aorta of the various groups at the end of the 7 weeks of animal modelling and treatment. BUN: blood urea nitrogen; Scr: serum creatinine. Control: the rats received standard diet and no intervention; OA: the rats received 2% OA diet to produce hyperuricemic model; OA + Allopurinol: the rats received 2% OA diet and drinking water dissolved in allopurinol; OA + SZF: the rats received 2% OA diet and Traditional Chinese Medicine formula of Shizhifang intragastrically. Data are expressed as the mean ± SD (). versus the OA group. versus the OA + Allopurinol group.

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