Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16/FOXO

Figure 4

The effect of GNC on the oxidative stress resistance of characterized mutant strains. Notes: survival curves of mutants under Cr (VI)-induced oxidative stress conditions: (a) eat-2 (ad465); (b) rsks-1 (ok1255); (c) isp-1 (qm150); (d) nuo-6 (qm200); (e) glp-1 (e2144); (f) daf-16 (mu86); (g) daf-2 (e1370); and (h) age-1 (hx546), pretreated with an H₂O control (black) or 3.94 mg/mL of GNC (grey). The protective effect of GNC depended on the function of daf-16 but was independent of the eat-2, rsks-1, isp-1, nuo-6, glp-1, daf-2, and age-1 genes.

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