Δ³,2-Hydroxybakuchiol Attenuates Depression in Multiple Rodent Models Possibly by Inhibition of Monoamine Transporters in Brain

Figure 5

Inhibition of hDAT and hNET by Δ³,2-hydroxybakuchiol in PC12 cells overexpressing hDAT or hNET. (a) The validity of stable transporter-overexpressing cells was confirmed by comparing the isotope uptake between PC12-overexpressing cells and naive cells. (b) IC₅₀ was calculated by the uptake inhibition under a serial of concentrations of Δ³,2-hydroxybakuchiol. Values are expressed as mean ± SEM. P < 0.005 versus naive cells.

(a)

(b)