The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers

Table 1

Average plasma silybin concentrations at various sampling times for all the volunteers after taking a single oral dose of silymarin SMEDDS soft capsules (n = 12).

Time (h)	Plasma silybin concentration (ng/ml)
0.0	0.00 ± 0.00
0.25	231.51 ± 413.00
0.50	610.71 ± 542.27
0.75	539.20 ± 368.87
10	364.05 ± 215.60
1.33	205.75 ± 126.04
1.67	134.66 ± 86.29
2.0	80.52 ± 53.85
2.5	38.86 ± 22.13
3.0	25.28 ± 18.79
4.0	12.60 ± 8.27
6.0	12.21 ± 11.38
8.0	7.09 + 1.82
10.0	7.88
12.0	-