The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers

Table 4

Pharmacokinetic parameters of silybin after the oral administration ofsilymarin SMEDDS soft capsules compared with conventional capsules from the published study.

PharmacokineticsParameters	Silybin (mean ± SD)
	Silymarin SMEDDS soft capsules	Published study
		Conventional capsule	Conventional
(h)	0.80 (0.25-1.67)	1.50 (0.50-8.0)	1.5
(/ngml)	812.43 ± 434.07	137.40 ± 51.83	167.3
(ng.h/ml)	658.80 ± 266.23	294.80 ± 95.58	N/A
(ng.h/ml)	676.98 ± 268.34	299.10 ± 96.00	406.5

Note. Published study conducted by Zhu and coworkers in 2013 [15].
Published study conducted by Brinda and coworkers in 2012 [16].
Median (range).
: maximum observed plasma concentration; : area under the plasma concentration versus time curve up to the last; : area under the plasma concentration versus time curve with the concentration extrapolated based on the elimination rate constant; : time to ; N/A: not available.