The Flavonoid Jaceosidin from Artemisia princeps Induces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells

Figure 4

Jaceosidin triggers cleavage of caspase-9, PARP, and caspase-3 and decreases Akt phosphorylation; OSCC cells were treated with the indicated concentrations of jaceosidin for 48 h and cleaved caspase-9, PARP, and caspase-3 proteins and phosphorylated Akt were examined using western blotting. Paclitaxel (PTX) was used as a positive control for caspase and PARP cleavage; (a) HSC-3 cells; (b) Ca9.22 cells.

(a) HSC-3

(b) Ca9.22